Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer

The clinical use of 5-fluorouracil, one of the drugs of choice in colon cancer therapy, is limited by a nonuniform oral absorption, a short plasma half-life, and by the development of drug resistances by malignant cells. We hypothesized that the formulation of biodegradable nanocarriers for the effi...

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Bibliografiske detaljer
Udgivet i:AAPS J
Main Authors: Ortiz, Raúl, Cabeza, Laura, Arias, José L., Melguizo, Consolación, Álvarez, Pablo J., Vélez, Celia, Clares, Beatriz, Áranega, Antonia, Prados, Jose
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476991/
https://ncbi.nlm.nih.gov/pubmed/25894746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9761-5
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