Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer

The clinical use of 5-fluorouracil, one of the drugs of choice in colon cancer therapy, is limited by a nonuniform oral absorption, a short plasma half-life, and by the development of drug resistances by malignant cells. We hypothesized that the formulation of biodegradable nanocarriers for the effi...

Full description

Saved in:
Bibliographic Details
Published in:AAPS J
Main Authors: Ortiz, Raúl, Cabeza, Laura, Arias, José L., Melguizo, Consolación, Álvarez, Pablo J., Vélez, Celia, Clares, Beatriz, Áranega, Antonia, Prados, Jose
Format: Artigo
Language:Inglês
Published: Springer US 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476991/
https://ncbi.nlm.nih.gov/pubmed/25894746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9761-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items