In Vitro, Pharmacokinetic, Pharmacodynamic, and Safety Comparisons of Single and Combined Administration of Tiotropium and Salmeterol in COPD Patients Using Different Dry Powder Inhalers

In vitro Andersen cascade impactor-sized mass (ISM) and aerodynamic fine particle mass (FPM) <5 μm for tiotropium and salmeterol combined in a novel inhalation powder formulation containing 7.5 μg tiotropium/25 μg salmeterol (TSHH) were similar (within ±15%) to reference products containing 18 μg...

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Detalles Bibliográficos
Publicado en:AAPS J
Autores principales: Horhota, Stephen T., van Noord, Jan A., Verkleij, Cynthia B., Bour, Loek J., Sharma, Ashish, Trunk, Michael, Cornelissen, Piet J. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476986/
https://ncbi.nlm.nih.gov/pubmed/25794622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9751-7
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