Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes

This study evaluated HIF-1α inhibitors under different hypoxic conditions, physiological hypoxia (5% O(2)) and severe hypoxia (0.1% O(2)). We found that chenodeoxy cholic acid (CDCA) reduced the amount of HIF-1α protein only under physiological hypoxia but not under severe hypoxia without decreasing...

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Bibliografiske detaljer
Udgivet i:	PLoS One
Main Authors:	Moon, Yunwon, Choi, Su Mi, Chang, Soojeong, Park, Bongju, Lee, Seongyeol, Lee, Mi-Ock, Choi, Hueng-Sik, Park, Hyunsung
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science 2015
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4476666/ https://ncbi.nlm.nih.gov/pubmed/26098428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130911
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Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes

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