Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

Formaldehyde is not only a widely used chemical with well-known carcinogenicity but is also a normal metabolite of living cells. It thus poses unique challenges for understanding risks associated with exposure. N(2-)hydroxymethyl-dG (N(2)-HOMe-dG) is the main formaldehyde-induced DNA mono-adduct, wh...

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Vydáno v:Toxicol Sci
Hlavní autoři: Yu, Rui, Lai, Yongquan, Hartwell, Hadley J., Moeller, Benjamin C., Doyle-Eisele, Melanie, Kracko, Dean, Bodnar, Wanda M., Starr, Thomas B., Swenberg, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Endogenous vs. Exogenous Formaldehyde DNA Damage
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476463/
https://ncbi.nlm.nih.gov/pubmed/25904104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv079
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