Comparative Risks of Aldehyde Constituents in Cigarette Smoke Using Transient Computational Fluid Dynamics/Physiologically Based Pharmacokinetic Models of the Rat and Human Respiratory Tracts

Computational fluid dynamics (CFD) modeling is well suited for addressing species-specific anatomy and physiology in calculating respiratory tissue exposures to inhaled materials. In this study, we overcame prior CFD model limitations to demonstrate the importance of realistic, transient breathing p...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Corley, Richard A., Kabilan, Senthil, Kuprat, Andrew P., Carson, James P., Jacob, Richard E., Minard, Kevin R., Teeguarden, Justin G., Timchalk, Charles, Pipavath, Sudhakar, Glenny, Robb, Einstein, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Modeling of Aldehydes from Cigarette Smoke
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476461/
https://ncbi.nlm.nih.gov/pubmed/25858911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv071
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