Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

AIMS: Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocy...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Moore, Samantha F., Williams, Christopher M., Brown, Edward, Blair, Thomas A., Harper, Matthew T., Coward, Richard J., Poole, Alastair W., Hers, Ingeborg
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476412/
https://ncbi.nlm.nih.gov/pubmed/25902782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv132
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