Immune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent

BACKGROUND: Deoxyribonucleic acid (DNA) vaccines are used for experimental immunotherapy of equine melanoma. The injection of complexed linear DNA encoding interleukin (IL)-12/IL-18 induced partial tumour remission in a clinical study including 27 grey horses. To date, the detailed mechanism of the...

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Pubblicato in:BMC Vet Res
Autori principali: Schnabel, Christiane L., Steinig, P., Koy, M., Schuberth, H.-J., Juhls, C., Oswald, D., Wittig, B., Willenbrock, S., Escobar, H. Murua, Pfarrer, C., Wagner, B., Jaehnig, P., Moritz, A., Feige, K., Cavalleri, J.-M. V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476236/
https://ncbi.nlm.nih.gov/pubmed/26100265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-015-0452-3
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