Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated Ca(V)1.3 Ca(2+) channels at hair cell active zones

Ca(2+) influx triggers the fusion of synaptic vesicles at the presynaptic active zone (AZ). Here we demonstrate a role of Ras-related in brain 3 (Rab3)–interacting molecules 2α and β (RIM2α and RIM2β) in clustering voltage-gated Ca(V)1.3 Ca(2+) channels at the AZs of sensory inner hair cells (IHCs)....

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Jung, Sangyong, Oshima-Takago, Tomoko, Chakrabarti, Rituparna, Wong, Aaron B., Jing, Zhizi, Yamanbaeva, Gulnara, Picher, Maria Magdalena, Wojcik, Sonja M., Göttfert, Fabian, Predoehl, Friederike, Michel, Katrin, Hell, Stefan W., Schoch, Susanne, Strenzke, Nicola, Wichmann, Carolin, Moser, Tobias
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475996/
https://ncbi.nlm.nih.gov/pubmed/26034270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417207112
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