Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders

Increasing evidence in the last years indicates that the vast amount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin structures. However, the impact of this spatial chromatin organization on gene expression and its degree of evolutionary conservation is...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Gómez-Marín, Carlos, Tena, Juan J., Acemel, Rafael D., López-Mayorga, Macarena, Naranjo, Silvia, de la Calle-Mustienes, Elisa, Maeso, Ignacio, Beccari, Leonardo, Aneas, Ivy, Vielmas, Erika, Bovolenta, Paola, Nobrega, Marcelo A., Carvajal, Jaime, Gómez-Skarmeta, José Luis
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475986/
https://ncbi.nlm.nih.gov/pubmed/26034287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505463112
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