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Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells
Pharmacological induction of the fetal γ globin gene and the consequent formation of HbF (α(2)/γ(2)) in adult erythroid cells are one feasible therapeutic strategy for sickle cell disease (SCD) and severe β-thalassemias. Hydroxyurea (HU) is the current drug of choice for SCD, but serious side effect...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4475914/ https://ncbi.nlm.nih.gov/pubmed/25986606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00035-15 |
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