Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function

Inhaled corticosteroid(s) (ICS) increase community-acquired pneumonia (CAP) incidence in patients with chronic obstructive pulmonary disease (COPD) by unknown mechanisms. Apoptosis is increased in the lungs of COPD patients. Uptake of apoptotic cells (AC) (“efferocytosis”) by alveolar macrophages (A...

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Veröffentlicht in:J Immunol
Hauptverfasser: Stolberg, Valerie R., McCubbrey, Alexandra L., Freeman, Christine M., Brown, Jeanette P., Crudgington, Sean W., Taitano, Sophina H., Saxton, Bridget L., Mancuso, Peter, Curtis, Jeffrey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475455/
https://ncbi.nlm.nih.gov/pubmed/25987742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402217
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