Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway

BACKGROUND: Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse. However, diagnosis of melioidosis can be difficult, especially in culture-negative cases. While metabolomics represe...

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Udgivet i:Cell Biosci
Main Authors: Lau, Susanna K. P., Lam, Ching-Wan, Curreem, Shirly O. T., Lee, Kim-Chung, Chow, Wang-Ngai, Lau, Candy C. Y., Sridhar, Siddharth, Wong, Sally C. Y., Martelli, Paolo, Hui, Suk-Wai, Yuen, Kwok-Yung, Woo, Patrick C. Y.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475313/
https://ncbi.nlm.nih.gov/pubmed/26097677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-015-0018-x
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