Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms

The Wilms’ tumor gene WT1 consists of 10 exons and encodes a zinc finger transcription factor. There are four major WT1 isoforms resulting from alternative splicing at two sites, exon 5 (17AA) and exon 9 (KTS). All major WT1 isoforms are overexpressed in leukemia and solid tumors and play oncogenic...

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Publicat a:PLoS One
Autors principals: Tatsumi, Naoya, Hojo, Nozomi, Sakamoto, Hiroyuki, Inaba, Rena, Moriguchi, Nahoko, Matsuno, Keiko, Fukuda, Mari, Matsumura, Akihide, Hayashi, Seiji, Morimoto, Soyoko, Nakata, Jun, Fujiki, Fumihiro, Nishida, Sumiyuki, Nakajima, Hiroko, Tsuboi, Akihiro, Oka, Yoshihiro, Hosen, Naoki, Sugiyama, Haruo, Oji, Yusuke
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474557/
https://ncbi.nlm.nih.gov/pubmed/26090994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130578
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