New Noncoding Lytic Transcripts Derived from the Epstein-Barr Virus Latency Origin of Replication, oriP, Are Hyperedited, Bind the Paraspeckle Protein, NONO/p54nrb, and Support Viral Lytic Transcription

We have previously shown that the Epstein-Barr virus (EBV) likely encodes hundreds of viral long noncoding RNAs (vlncRNAs) that are expressed during reactivation. Here we show that the EBV latency origin of replication (oriP) is transcribed bi-directionally during reactivation and that both leftward...

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Veröffentlicht in:J Virol
Hauptverfasser: Cao, Subing, Moss, Walter, O'Grady, Tina, Concha, Monica, Strong, Michael J., Wang, Xia, Yu, Yi, Baddoo, Melody, Zhang, Kun, Fewell, Claire, Lin, Zhen, Dong, Yan, Flemington, Erik K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473578/
https://ncbi.nlm.nih.gov/pubmed/25926645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00608-15
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