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Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases

Approximately one-third of proteins in the cell reside in the membrane. Mutations in membrane proteins can induce conformational changes and expose nonnative polar domains/residues to the lipid environment. The molecular effect of the resulting membrane stress is poorly defined. Adenine nucleotide t...

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Publicado en:Mol Biol Cell
Main Authors: Liu, Yaxin, Wang, Xiaowen, Chen, Xin Jie
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472010/
https://ncbi.nlm.nih.gov/pubmed/25833713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-01-0030
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