Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells.

Exposure of ornithine decarboxylase (ODC; L-ornithine carboxy-lyase, EC 4.1.1.17)-overproducing mouse FM3A cells to micromolar levels of spermine or spermidine caused abnormal accumulation and toxicity of polyamines. This was apparently due to the inefficiency of negative feedback control of polyami...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Suzuki, T, He, Y, Kashiwagi, K, Murakami, Y, Hayashi, S, Igarashi, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8090747/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.8930
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