Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

Excessive microglial activation often contributes to inflammation-mediated neurotoxicity in the ischemic penumbra during the acute stage of ischemic stroke. Toll-like receptor 4 (TLR4) has been reported to induce microglial activation via the NF-κB pathway. Isoflurane preconditioning (IP) can provid...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sun, Meiyan, Deng, Bin, Zhao, Xiaoyong, Gao, Changjun, Yang, Lu, Zhao, Hui, Yu, Daihua, Zhang, Feng, Xu, Lixian, Chen, Lei, Sun, Xude
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471883/
https://ncbi.nlm.nih.gov/pubmed/26086415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11445
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