Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPARγ and Fatty Acid Uptake

Transgenic mice (Tg) overexpressing human apolipoprotein D (H-apoD) in the brain are resistant to neurodegeneration. Despite the use of a neuron-specific promoter to generate the Tg mice, they expressed significant levels of H-apoD in both plasma and liver and they slowly develop hepatic steatosis a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Labrie, Marilyne, Lalonde, Simon, Najyb, Ouafa, Thiery, Maxime, Daneault, Caroline, Des Rosiers, Chrisitne, Rassart, Eric, Mounier, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470830/
https://ncbi.nlm.nih.gov/pubmed/26083030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130230
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