A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed / Refractory Acute Lymphoblastic Leukemia

PURPOSE: Previous studies suggest a potential therapeutic role for mTOR inhibition in lymphoid malignancies. This single-center phase I/II study was designed to test the safety and efficacy of the mTOR inhibitor everolimus in combination with HyperCVAD chemotherapy in relapsed/refractory acute lymph...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Daver, Naval, Boumber, Yanis, Kantarjian, Hagop, Ravandi, Farhad, Cortes, Jorge, Rytting, Michael E., Kawedia, Jitesh D., Basnett, Jordan, Culotta, Kirk S., Zeng, Zhihong, Lu, Hongbo, Richie, Mary Ann, Garris, Rebecca, Xiao, Lianchun, Liu, Wenbin, Baggerly, Keith A., Jabbour, Elias, O’Brien, Susan, Burger, Jan, Bendall, Linda J., Thomas, Deborah, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470787/
https://ncbi.nlm.nih.gov/pubmed/25724525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2888
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