A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed / Refractory Acute Lymphoblastic Leukemia

PURPOSE: Previous studies suggest a potential therapeutic role for mTOR inhibition in lymphoid malignancies. This single-center phase I/II study was designed to test the safety and efficacy of the mTOR inhibitor everolimus in combination with HyperCVAD chemotherapy in relapsed/refractory acute lymph...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Daver, Naval, Boumber, Yanis, Kantarjian, Hagop, Ravandi, Farhad, Cortes, Jorge, Rytting, Michael E., Kawedia, Jitesh D., Basnett, Jordan, Culotta, Kirk S., Zeng, Zhihong, Lu, Hongbo, Richie, Mary Ann, Garris, Rebecca, Xiao, Lianchun, Liu, Wenbin, Baggerly, Keith A., Jabbour, Elias, O’Brien, Susan, Burger, Jan, Bendall, Linda J., Thomas, Deborah, Konopleva, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470787/
https://ncbi.nlm.nih.gov/pubmed/25724525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2888
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