A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed / Refractory Acute Lymphoblastic Leukemia

PURPOSE: Previous studies suggest a potential therapeutic role for mTOR inhibition in lymphoid malignancies. This single-center phase I/II study was designed to test the safety and efficacy of the mTOR inhibitor everolimus in combination with HyperCVAD chemotherapy in relapsed/refractory acute lymph...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Daver, Naval, Boumber, Yanis, Kantarjian, Hagop, Ravandi, Farhad, Cortes, Jorge, Rytting, Michael E., Kawedia, Jitesh D., Basnett, Jordan, Culotta, Kirk S., Zeng, Zhihong, Lu, Hongbo, Richie, Mary Ann, Garris, Rebecca, Xiao, Lianchun, Liu, Wenbin, Baggerly, Keith A., Jabbour, Elias, O’Brien, Susan, Burger, Jan, Bendall, Linda J., Thomas, Deborah, Konopleva, Marina
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470787/
https://ncbi.nlm.nih.gov/pubmed/25724525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2888
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