Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

BACKGROUND: Glioblastomas are invasive therapy resistant brain tumors with extremely poor prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance and tumor recurrence. Targeting GIC-associated gene candidates could significantly impact GBM tumorigenicity. Here, w...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Joel, Mrinal, Mughal, Awais A., Grieg, Zanina, Murrell, Wayne, Palmero, Sheryl, Mikkelsen, Birthe, Fjerdingstad, Hege B., Sandberg, Cecilie J., Behnan, Jinan, Glover, Joel C., Langmoen, Iver A., Stangeland, Biljana
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470057/
https://ncbi.nlm.nih.gov/pubmed/26081429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0398-x
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