Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines

Yessotoxin (YTX) modulates cellular phosphodiesterases (PDEs). In this regard, opposite effects had been described in the tumor model K-562 cell line and fresh human lymphocytes in terms of cell viability, cyclic adenosine 3',5'-cyclic monophosphate (cAMP) production and protein expression...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Fernández-Araujo, Andrea, Sánchez, Jon A., Alfonso, Amparo, Vieytes, Mercedes R., Botana, Luis M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469822/
https://ncbi.nlm.nih.gov/pubmed/26136685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00124
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