Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

BACKGROUND/OBJECTIVES: Induced pluripotent stem cells (iPS) exhibit enhanced survival and proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited by their tumorigenic potential. We hypothesized that iPS cells can transmit cytoprotective signals to cardiomyocyt...

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Veröffentlicht in:Int J Cardiol
Hauptverfasser: Wang, Yingjie, Zhang, Lan, Li, Yongjun, Chen, Lijuan, Wang, Xiaolong, Guo, Wei, Zhang, Xue, Qin, Gangjian, He, Sheng-hu, Zimmerman, Arthur, Liu, Yutao, Kim, Il-man, Weintraub, Neal L., Tang, Yaoliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469495/
https://ncbi.nlm.nih.gov/pubmed/26000464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2015.05.020
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