Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

BACKGROUND/OBJECTIVES: Induced pluripotent stem cells (iPS) exhibit enhanced survival and proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited by their tumorigenic potential. We hypothesized that iPS cells can transmit cytoprotective signals to cardiomyocyt...

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Detalhes bibliográficos
Publicado no:Int J Cardiol
Main Authors: Wang, Yingjie, Zhang, Lan, Li, Yongjun, Chen, Lijuan, Wang, Xiaolong, Guo, Wei, Zhang, Xue, Qin, Gangjian, He, Sheng-hu, Zimmerman, Arthur, Liu, Yutao, Kim, Il-man, Weintraub, Neal L., Tang, Yaoliang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469495/
https://ncbi.nlm.nih.gov/pubmed/26000464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2015.05.020
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