Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR)...

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Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Yu, Miao, Youngsaye, Willmen, Nag, Partha P., Bennion, Melissa, Penman, Marsha, Nieland, Thomas J. F., Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469081/
https://ncbi.nlm.nih.gov/pubmed/25958245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.074
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