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Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia

IMPORTANCE: The core clinical and neuropathological feature of the autosomal dominant spinocerebellar ataxias (SCAs) is cerebellar degeneration. Mutations in the known genes explain only 50% to 60% of SCA cases. To date, no effective treatments exist, and the knowledge of drug-treatable molecular pa...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Bettencourt, Conceição, Ryten, Mina, Forabosco, Paola, Schorge, Stephanie, Hersheson, Joshua, Hardy, John, Houlden, Henry
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469030/
https://ncbi.nlm.nih.gov/pubmed/24862029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.756
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