Optimization of Polyene-Azole Combination Therapy against Aspergillosis Using an In Vitro Pharmacokinetic-Pharmacodynamic Model

Although amphotericin B-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully to treat refractory invasive aspergillosis. So far, pharmacodynamic (PD) interactions have been assessed with conventional in vitro tests, whi...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Siopi, Maria, Siafakas, Nikolaos, Vourli, Sophia, Zerva, Loukia, Meletiadis, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468736/
https://ncbi.nlm.nih.gov/pubmed/25896699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05035-14
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