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Phosphine Mediated Conjugation of S-Nitrosothiols and Aldehydes

S-Nitrosothiols (SNO) and their biological implications as an important post-translational modification are under active investigation. In our work on bioorthogonal reactions of protein SNO we have uncovered chemistry of this functionality that shows synthetic promise. Herein we report a phosphine-m...

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Publicat a:Tetrahedron Lett
Autors principals: Biggs, Tyler D., Weerasinghe, Laksiri, Park, Chung-Min, Xian, Ming
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467916/
https://ncbi.nlm.nih.gov/pubmed/26089576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.04.017
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