Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

To elucidate the precise metabolic roles of hepatic lipase (HL), a human HL cDNA in a liver-specific expression vector was used to generate transgenic lines in the rabbit, an animal that normally expresses low levels of this enzyme. HL was detected in the plasma of all rabbits only after the adminis...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Fan, J, Wang, J, Bensadoun, A, Lauer, S J, Dang, Q, Mahley, R W, Taylor, J M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078949/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8724
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