Modification of the Association between Lead Exposure and Amyotrophic Lateral Sclerosis by Iron and Oxidative Stress Related Gene Polymorphisms

OBJECTIVE: To examine whether functional polymorphisms in hemochromatosis (HFE; H63D and C282Y), transferrin (TfC2), and glutathione-s-transferase Pi1 (GSTP1; Ile105Val) genes modify any lead-ALS association. METHODS: We measured blood lead using atomic absorption spectroscopy and bone lead—a biomar...

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Pubblicato in:Amyotroph Lateral Scler Frontotemporal Degener
Autori principali: Eum, Ki-Do, Seals, Ryan M., Taylor, Kathryn M., Grespin, Matthew, Umbach, David M., Hu, Howard, Sandler, Dale P., Kamel, Freya, Weisskopf, Marc G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467726/
https://ncbi.nlm.nih.gov/pubmed/25293352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21678421.2014.964259
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