Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresista...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Wang, Huiru, Sun, Qing, Wu, Yanhong, Wang, Lin, Zhou, Chunxia, Ma, Wenbo, Zhang, Youhui, Wang, Shengdian, Zhang, Shuren
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467404/
https://ncbi.nlm.nih.gov/pubmed/25788270
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