Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor

ST7612AA1 (property of Sigma-Tau), a thioacetate-ω (γ-lactam amide) derivative, is a potent, second generation, oral pan-histone deacetylase inhibitor (HDACi). Aim of the study was to assess the efficacy of ST7612AA1 in solid and haematological tumors, and to characterize its mec...

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Vydáno v:Oncotarget
Hlavní autoři: Vesci, Loredana, Bernasconi, Elena, Milazzo, Ferdinando Maria, De Santis, Rita, Gaudio, Eugenio, Kwee, Ivo, Rinaldi, Andrea, Pace, Silvia, Carollo, Valeria, Giannini, Giuseppe, Bertoni, Francesco
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467398/
https://ncbi.nlm.nih.gov/pubmed/25671299
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