miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/tumor initiating cell properties

Renal cell carcinoma (RCC) is an aggressive disease, with 35% chance of metastasis. The ‘cancer stem cell’ hypothesis suggests that a subset of cancer cells possess stem cell properties and is crucial in tumor initiation, metastasis and treatment resistance. We isolated RCC spheres and showed that t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lichner, Zsuzsanna, Saleh, Carol, Subramaniam, Venkateswaran, Seivwright, Annetta, Prud'homme, Gerald Joseph, Yousef, George Makram
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467387/
https://ncbi.nlm.nih.gov/pubmed/25011053
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