Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells

Mast cell differentiation and proliferation depends on IL-3. IL-3 induces the activation of MAP-kinases and STATs and consequently induces proliferation and survival. Dysregulation of IL-3 signaling pathways also contribute to inflammation and tumorigenesis. We show here that IL-3 induces a SFK- and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Drube, Sebastian, Weber, Franziska, Loschinski, Romy, Beyer, Mandy, Rothe, Mandy, Rabenhorst, Anja, Göpfert, Christiane, Meininger, Isabel, Diamanti, Michaela A., Stegner, David, Häfner, Norman, Böttcher, Martin, Reinecke, Kirstin, Herdegen, Thomas, Greten, Florian R., Nieswandt, Bernhard, Hartmann, Karin, Krämer, Oliver H., Kamradt, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467154/
https://ncbi.nlm.nih.gov/pubmed/25749030
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