Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Transmembrane proteins MUC4, EGFR and HER2 are shown to be critical in invasion and metastasis of pancreatic cancer. Besides, we and others have demonstrated de novo expression of MUC4 in ~70-90% of pancreatic cancer patients and its stabilizing effects on HER2 downstream signaling in pancreatic can...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Seshacharyulu, Parthasarathy, Ponnusamy, Moorthy P., Rachagani, Satyanarayana, Lakshmanan, Imayavaramban, Haridas, Dhanya, Yan, Ying, Ganti, Apar K., Batra, Surinder K.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467140/
https://ncbi.nlm.nih.gov/pubmed/25686822
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