Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response

We investigated the pre-clinical activities of two novel histone deacetylase inhibitors (HDACi), ITF-A and ITF-B, in a large panel of pre-clinical lymphoma models. The two compounds showed a dose-dependent anti-proliferative activity in the majority of cell lines. Gene expression profiling (GEP) of...

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發表在:Oncotarget
Main Authors: Mensah, Afua Adjeiwaa, Kwee, Ivo, Gaudio, Eugenio, Rinaldi, Andrea, Ponzoni, Maurilio, Cascione, Luciano, Fossati, Gianluca, Stathis, Anastasios, Zucca, Emanuele, Caprini, Gianluca, Bertoni, Francesco
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2014
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467133/
https://ncbi.nlm.nih.gov/pubmed/25671298
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