Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias

Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to disrupted neuronal function and can cause Rett syndrome (RTT), a neurodevelopmental disorder. Previous studies reported cardiac dysfunction, i...

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Publicado no:Sci Rep
Main Authors: Hara, Munetsugu, Takahashi, Tomoyuki, Mitsumasu, Chiaki, Igata, Sachiyo, Takano, Makoto, Minami, Tomoko, Yasukawa, Hideo, Okayama, Satoko, Nakamura, Keiichiro, Okabe, Yasunori, Tanaka, Eiichiro, Takemura, Genzou, Kosai, Ken-ichiro, Yamashita, Yushiro, Matsuishi, Toyojiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466896/
https://ncbi.nlm.nih.gov/pubmed/26073556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11204
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