Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21(Cip1) and p27(Kip1)

Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1–3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arres...

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Publicado en:Oncotarget
Autores principales: Lin, Hui-Ping, Lin, Ching-Yu, Huo, Chieh, Hsiao, Ping-Hsuan, Su, Liang-Cheng, Jiang, Shih Sheng, Chan, Tzu-Min, Chang, Chung-Ho, Chen, Li-Tzong, Kung, Hsing-Jien, Wang, Horng-Dar, Chuu, Chih-Pin
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466643/
https://ncbi.nlm.nih.gov/pubmed/25788262
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