The 4G/4G Genotype of PAI-1 Polymorphism Is Associated with Higher Plasma PAI-1 Concentrations and Mortality in Patients with Severe Sepsis

OBJECTIVE: Two studies have reported that patients with the 4G/4G genotype of the plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism had higher plasma PAI-1 concentrations and higher risk of death than those with the 4G/5G or 5G/5G genotypes; one study involved 175 children with meningoc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lorente, Leonardo, Martín, María M., Borreguero-León, Juan M., Barrios, Ysamar, Solé-Violán, Jordi, Ferreres, José, Labarta, Lorenzo, Díaz, César, Jiménez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466252/
https://ncbi.nlm.nih.gov/pubmed/26066833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129565
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