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Amelioration Strategies Fail To Prevent Tobacco Smoke Effects On Neurodifferentiation: Nicotinic Receptor Blockade, Antioxidants, Methyl Donors

Tobacco smoke exposure is associated with neurodevelopmental disorders. We used neuronotypic PC12 cells to evaluate the mechanisms by which tobacco smoke extract (TSE) affects neurodifferentiation. In undifferentiated cells, TSE impaired DNA synthesis and cell numbers to a much greater extent than n...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Slotkin, Theodore A., Skavicus, Samantha, Card, Jennifer, Levin, Edward D., Seidler, Frederic J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466202/
https://ncbi.nlm.nih.gov/pubmed/25891525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.04.005
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