Bone Metastasis in Prostate Cancer: Recurring Mitochondrial DNA Mutation Reveals Selective Pressure Exerted by the Bone Microenvironment

BACKGROUND: Cancer progression and metastasis occurs such that cells with acquired mutations enhancing growth and survival (or inhibiting cell death) increase in number, a concept that has been recognized as analogous to Darwinian evolution of species since Peter C. Nowell’s description in 1976. Sel...

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Publicado en:Bone
Main Authors: Arnold, Rebecca S., Fedewa, Stacey A., Goodman, Michael, Osunkoya, Adeboye O., Kissick, Haydn T., Morrissey, Colm, True, Lawrence D., Petros, John A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466124/
https://ncbi.nlm.nih.gov/pubmed/25952970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.04.046
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