Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Metabotropic glutamate receptor 4 (mGlu(4)) negatively modulates GABA and glutamate release in the ‘indirect pathway’ of the basal ganglia, and has thus been proposed as a potential target to treat motor symptoms in Parkinson's disease. Here, we present an extensive comparison of the behavioura...

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Publicado no:Neuropharmacology
Main Authors: Iderberg, Hanna, Maslava, Natallia, Thompson, Analisa D., Bubser, Michael, Niswender, Colleen M., Hopkins, Corey R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K., Cenci, M. Angela
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466038/
https://ncbi.nlm.nih.gov/pubmed/25749357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.02.023
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