Reducing alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4)

RATIONALE: Phosphodiesterase-4 (PDE4) and neuroimmune signaling have been posited to regulate alcohol drinking. OBJECTIVES: This study evaluated the involvement of PDE4 and Il22ra2 on ethanol (EtOH) intake by alcohol-preferring (P) and high-alcohol drinking (HAD1) rats. METHODS: Exp 1 determined the...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Franklin, Kelle M., Hauser, Sheketha R., Lasek, Amy W., McClintick, Jeanette, Ding, Zheng-Ming, McBride, William J., Bell, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465875/
https://ncbi.nlm.nih.gov/pubmed/25585681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3852-3
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