Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats

BACKGROUND: Both angiotensin II type 1 receptor (AT(1)R) and nuclear factor-kappa B (NF-κB) play significant roles in the pathogenesis of hypertension and type 2 diabetes. However, the role of NF-κB in perpetuating renal AT(1) receptors dysfunction remains unclear. The aim of the present study to de...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Luo, Hao, Wang, Xinquan, Wang, Jialiang, Chen, Caiyu, Wang, Na, Xu, Zaicheng, Chen, Shuo, Zeng, Chunyu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465496/
https://ncbi.nlm.nih.gov/pubmed/26055622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0239-7
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