More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer’s disease risk

Over twenty risk loci have been identified for late onset Alzheimer’s disease (LOAD), most of which display relatively small effect sizes. Recently, a rare missense (R47H) variant, rs75932628 in TREM2, has been shown to mediate LOAD risk substantially in Icelandic and Caucasian populations. Here we...

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Publicado en:Neurobiol Aging
Main Authors: Rosenthal, Samantha L., Bamne, Mikhil N., Wang, Xingbin, Berman, Sarah, Snitz, Beth E., Klunk, William E., Sweet, Robert A., Demirci, F. Yesim, Lopez, Oscar L., Kamboh, M. Ilyas
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465085/
https://ncbi.nlm.nih.gov/pubmed/26058841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.04.012
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