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Enhanced expression of epithelial sodium channels causes salt-induced hypertension in mice through inhibition of the α(2)-isoform of Na(+), K(+)-ATPase
Knockout of the Nedd4-2 gene in mice results in overexpression of epithelial sodium channels (ENaC) on the plasma membrane in the kidney, choroid plexus and brain nuclei. These mice exhibit enhanced pressor responses to CSF [Na(+)] as well as dietary salt-induced hypertension which both can be block...
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| Publicado no: | Physiol Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4463818/ https://ncbi.nlm.nih.gov/pubmed/25991719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12383 |
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