MEL-18 loss mediates estrogen receptor–α downregulation and hormone independence

The polycomb protein MEL-18 has been proposed as a tumor suppressor in breast cancer; however, its functional relevance to the hormonal regulation of breast cancer remains unknown. Here, we demonstrated that MEL-18 loss contributes to the hormone-independent phenotype of breast cancer by modulating...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Lee, Jeong-Yeon, Won, Hee-Young, Park, Ji-Hye, Kim, Hye-Yeon, Choi, Hee-Joo, Shin, Dong-Hui, Kang, Ju-Hee, Woo, Jong-Kyu, Oh, Seung-Hyun, Son, Taekwon, Choi, Jin-Woo, Kim, Sehwan, Kim, Hyung-Yong, Yi, Kijong, Jang, Ki-Seok, Oh, Young-Ha, Kong, Gu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463188/
https://ncbi.nlm.nih.gov/pubmed/25822021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73743
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