Development of a Model System for Tick-Borne Flavivirus Persistence in HEK 293T Cells

We devised a model system to study persistent infection by the tick-borne flavivirus Langat virus (LGTV) in 293T cells. Infection with a molecularly cloned LGTV strain produced an acute lytic crisis that left few surviving cells. The culture was repopulated by cells that were ~90% positive for LGTV...

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Bibliographic Details
Published in:mBio
Main Authors: Mlera, Luwanika, Offerdahl, Danielle K., Martens, Craig, Porcella, Stephen F., Melik, Wessam, Bloom, Marshall E.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462619/
https://ncbi.nlm.nih.gov/pubmed/26045539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00614-15
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