Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

INTRODUCTION: We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing cell vaccine. Since IL-12 can induce the release of interleukin-15 (IL-15), in the present study we investigated the role playe...

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Published in:Breast Cancer Res
Main Authors: Croci, Stefania, Nanni, Patrizia, Palladini, Arianna, Nicoletti, Giordano, Grosso, Valentina, Benegiamo, Giorgia, Landuzzi, Lorena, Lamolinara, Alessia, Ianzano, Marianna L., Ranieri, Dario, Dall’Ora, Massimiliano, Iezzi, Manuela, De Giovanni, Carla, Lollini, Pier-Luigi
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462012/
https://ncbi.nlm.nih.gov/pubmed/25997501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0588-x
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