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Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P(2) in regulating insulin sensitivity defined by knock-in analysis
Insulin sensitivity is critically dependent on the activity of PI3K (phosphoinositide 3-kinase) and generation of the PtdIns(3,4,5)P(3) second messenger. PtdIns(3,4,5)P(3) can be broken down to PtdIns(3,4)P(2) through the action of the SHIPs (Src-homology-2-domain-containing inositol phosphatases)....
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| Publicado no: | Biochem J |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461655/ https://ncbi.nlm.nih.gov/pubmed/21204784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20102012 |
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