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Orthogonal control of expression mean and variance by epigenetic features at different genomic loci

While gene expression noise has been shown to drive dramatic phenotypic variations, the molecular basis for this variability in mammalian systems is not well understood. Gene expression has been shown to be regulated by promoter architecture and the associated chromatin environment. However, the exa...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Dey, Siddharth S, Foley, Jonathan E, Limsirichai, Prajit, Schaffer, David V, Arkin, Adam P
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461400/
https://ncbi.nlm.nih.gov/pubmed/25943345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145704
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