Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice

We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects of QL alone with those of QL combined with the following 3 types of antihypertensive drugs on cardiac remodeling and dysfuncti...

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Julkaisussa:J Cardiovasc Pharmacol
Päätekijät: Ye, Yong, Gong, Hui, Wang, Xingxu, Wu, Jian, Wang, Shijun, Yuan, Jie, Yin, Peipei, Jiang, Guoliang, Li, Yang, Ding, Zhiwen, Zhang, Weijing, Zhou, Jingmin, Ge, Junbo, Zou, Yunzeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Journal of Cardiovascular Pharmacology 2015
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461387/
https://ncbi.nlm.nih.gov/pubmed/25806688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000230
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spelling pubmed-44613872016-01-28 Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice Ye, Yong Gong, Hui Wang, Xingxu Wu, Jian Wang, Shijun Yuan, Jie Yin, Peipei Jiang, Guoliang Li, Yang Ding, Zhiwen Zhang, Weijing Zhou, Jingmin Ge, Junbo Zou, Yunzeng J Cardiovasc Pharmacol Original Article We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects of QL alone with those of QL combined with the following 3 types of antihypertensive drugs on cardiac remodeling and dysfunction induced by pressure overload for 4 weeks in mice: an angiotensin II type 1 receptor (AT(1)-R) blocker (ARB), an angiotensin-converting enzyme inhibitor (ACEI), and a β-adrenergic receptor (β-AR) blocker (BB). Adult male mice (C57B/L6) were subjected to either transverse aortic constriction or sham operation for 4 weeks, and the drugs (or saline) were orally administered through gastric tubes. Cardiac function and remodeling were evaluated through echocardiography, catheterization, histology, and analysis of hypertrophic gene expression. Cardiomyocyte apoptosis and autophagy, AT(1)-R and β(1)-AR expression, and cell proliferation–related molecules were also examined. Although pressure overload–induced cardiac remodeling and dysfunction, hypertrophic gene reprogramming, AT(1)-R and β(1)-AR expression, and ERK phosphorylation were significantly attenuated by QL alone, QL + ARB, QL + ACEI, and QL + BB, the attenuation was stronger in the combination treatment groups. Moreover, apoptosis was reduced to a larger extent by each combination treatment than by QL alone, whereas autophagy was more strongly attenuated by either QL + ARB or QL + ACEI. None of the treatments significantly upregulated ErbB2 or ErbB4 phosphorylation, and none significantly downregulated C/EBPβ expression. Therefore, the effects of QL on chronic pressure overload–induced cardiac remodeling may be significantly increased when QL is combined with an ARB, an ACEI, or a BB. Journal of Cardiovascular Pharmacology 2015-06 2015-06-09 /pmc/articles/PMC4461387/ /pubmed/25806688 http://dx.doi.org/10.1097/FJC.0000000000000230 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Original Article
spellingShingle Original Article
Ye, Yong
Gong, Hui
Wang, Xingxu
Wu, Jian
Wang, Shijun
Yuan, Jie
Yin, Peipei
Jiang, Guoliang
Li, Yang
Ding, Zhiwen
Zhang, Weijing
Zhou, Jingmin
Ge, Junbo
Zou, Yunzeng
Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
description We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects of QL alone with those of QL combined with the following 3 types of antihypertensive drugs on cardiac remodeling and dysfunction induced by pressure overload for 4 weeks in mice: an angiotensin II type 1 receptor (AT(1)-R) blocker (ARB), an angiotensin-converting enzyme inhibitor (ACEI), and a β-adrenergic receptor (β-AR) blocker (BB). Adult male mice (C57B/L6) were subjected to either transverse aortic constriction or sham operation for 4 weeks, and the drugs (or saline) were orally administered through gastric tubes. Cardiac function and remodeling were evaluated through echocardiography, catheterization, histology, and analysis of hypertrophic gene expression. Cardiomyocyte apoptosis and autophagy, AT(1)-R and β(1)-AR expression, and cell proliferation–related molecules were also examined. Although pressure overload–induced cardiac remodeling and dysfunction, hypertrophic gene reprogramming, AT(1)-R and β(1)-AR expression, and ERK phosphorylation were significantly attenuated by QL alone, QL + ARB, QL + ACEI, and QL + BB, the attenuation was stronger in the combination treatment groups. Moreover, apoptosis was reduced to a larger extent by each combination treatment than by QL alone, whereas autophagy was more strongly attenuated by either QL + ARB or QL + ACEI. None of the treatments significantly upregulated ErbB2 or ErbB4 phosphorylation, and none significantly downregulated C/EBPβ expression. Therefore, the effects of QL on chronic pressure overload–induced cardiac remodeling may be significantly increased when QL is combined with an ARB, an ACEI, or a BB.
author Ye, Yong
Gong, Hui
Wang, Xingxu
Wu, Jian
Wang, Shijun
Yuan, Jie
Yin, Peipei
Jiang, Guoliang
Li, Yang
Ding, Zhiwen
Zhang, Weijing
Zhou, Jingmin
Ge, Junbo
Zou, Yunzeng
author_facet Ye, Yong
Gong, Hui
Wang, Xingxu
Wu, Jian
Wang, Shijun
Yuan, Jie
Yin, Peipei
Jiang, Guoliang
Li, Yang
Ding, Zhiwen
Zhang, Weijing
Zhou, Jingmin
Ge, Junbo
Zou, Yunzeng
author_sort Ye, Yong
title Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
title_short Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
title_full Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
title_fullStr Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
title_full_unstemmed Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload–induced Cardiac Hypertrophy and Remodeling in Male Mice
title_sort combination treatment with antihypertensive agents enhances the effect of qiliqiangxin on chronic pressure overload–induced cardiac hypertrophy and remodeling in male mice
publisher Journal of Cardiovascular Pharmacology
container_title J Cardiovasc Pharmacol
publishDate 2015
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4461387/
https://ncbi.nlm.nih.gov/pubmed/25806688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000230
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